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A breakthrough diet pill that attacks cravings and appetite.

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While most diet pills are a dime a dozen, once in awhile a promising weight loss pill hits the market that causes even the most skeptical of medical professionals to stop and listen. Contrave is one such product.

Developed by Orexigen Therapeutics, Contrave is actually the combination of two different drugs: The antidepressant medication, buproprion, or Wellbutrin, and the drug naltrexone, which is used to treat alcohol and opiate addiction.

Rather than working to block fat or starches like many prescribed diet pills do, Contrave unleashes its power on the brain, where it works to quell cravings in the brain's highly complex behavior-reward center, and also to temper appetite.

In late-stage clinical trials, Contrave has fared much better than the FDA's standards for improving weight loss, exceeding by five percent. Rather, those who took Contrave while also following a diet and exercise program lost between nine and 15 percent of their body weight while those who did not lost just about five percent of their body weight.

Contrave has also shown few side effects and notably absent are mental health and uncomfortable physical side effects that often come from taking weight loss pills. In fact, those studied showed an improved quality of life while taking the pill.

Contrave is being slated as a chronic diet pill; if you take it and lose weight you will have to continue to take it in order to maintain lost weight. One of the downfalls with most of the diet pills on the market, whether or not they require a prescription, is that once you stop taking them, weight is easily regained. Since Contrave specifically acts on the centers of the brain that govern overeating behaviors and craving desires, there is hope that its ability to suppress these processes will lead to long-term weight loss.

As of July 2009, Orexigen Therapeutics is seeking FDA approval. When and if Contrave is approved for consumer use, it will require a prescription from a medical professional.

  • Shows promise in late-stage clinical trials
  • Exceeding FDA standards in trials
  • Cocktail-like therapy may be the benchmark for future diet pills
  • Few side effects
  • Weight loss is greater than placebo alone
  • If approved, requires a prescription
  • May need to take diet pill chronically
  • Weight loss advantage is not that significant
  • Not a magic solution to healthy eating behaviors and to a healthy weight
  • Still awaiting FDA approval

Contrave is a breakthrough weight loss drug because it contains both buproprion and naltrexone.

Buprupion is also known as the branded prescription drug Wellbutrin, a quality anti-depressant.

Naltrexone is a prescription drug used to treat addiction, in cases such as smoking, alcohol or even opiates.


Contrave will likely be taken daily. Since the drug is awaiting FDA approval, precise dosage instructions are not yet available.


A low-fat and low-calorie diet and regular exercise program is followed while taking Contrave. Since this drug does not act on the stomach, there are currently no specific foods that need to be avoided or a particular style of eating that needs to be followed while taking it.


Contrave is a new weight loss pill that shows promise for being able to act on the brain's pathways that control cravings and appetite. This new kind of drug, which combines two different kinds of psychopharmaceuticals, is predicted to be the wave of the future for diet pills.

Contrave is still awaiting FDA approval.

Common Misspellings

contrav, contreve, contrive, contrave diet, contrave diet pill, wellbutrin diet pill, crave diet pills, cuntrave, contreav

Related Diets: Alli, Orlistat, Xenical

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(Page 1 of 1, 11 total comments)


Why would anybody take Contrave when Belviq is available which is so much cleaner and works just as well.

posted Nov 22nd, 2014 2:37 am


Horrible side effects!

posted Nov 22nd, 2014 2:37 am


Terrible side effects. Can make you feel sick!

posted Nov 22nd, 2014 2:34 am


Suicidal side effects? No thanks. Belviq is much much safer.

posted Nov 22nd, 2014 2:34 am

jc carvill

i would like to try. maybe better than the other one , Q and B.

posted Oct 30th, 2014 7:40 am


Sounds awesome! So it can be taken for life?

posted Sep 19th, 2014 3:37 am

Beth walters

Lowering carb and increasing protein intake is essential for maintaining healthy weight loss. Why wasn't that included in the advertisement?

posted Sep 13th, 2014 12:23 pm

mohammad naeem

where can i buy it i have type 2 diabeties

posted Sep 13th, 2014 12:32 am



posted Oct 1st, 2011 3:21 pm


Has this drug been approved yet?

posted May 23rd, 2011 12:15 am


I took this medication for 52+ weeks and lost 14 % of my body weight. started out out of shape and I walked until I could walk 1 mile a day. I was so depressed and this medication helped me alot. I miss it. I can't wait for it to be FDA approved. I felt good.

posted Feb 16th, 2010 4:44 pm


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