Lorcaserin

BACKGROUND Start the Diet Now Advertisement

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Lorcaserin is a new prescription weight loss drug manufactured by Arena Pharmaceuticals, Inc. It is one of three different weight loss pills that are undergoing final approval by the FDA in 2010.

Lorcaserin is a new class of selective serotonin 2C receptor agonists. The serotonin 2C receptor is expressed in the areas of the brain that are involved in the control of appetite and metabolism. Stimulation of this receptor is strongly associated with reducing hunger and increasing satiety.

In a largescale study, patients who took Lorcaserin lost five percent of their body weight in comparison to a placebo group. Lorcaserin patients also achieved greater improvements in total cholesterol, triglycerides, HDL cholesterol and insulin resistance compared to placebo across all subgroups. Greater improvements were also seen in fasting insulin, fasting glucose and blood pressure for Lorcaserin patients compared to placebo overall and in most subgroups.

PRO

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• May help those who are obese or very overweight start gain to control over their health
• May help to produce intended effects
• Must meet FDA approval
• Produces minimal side effects in comparison to other medically-prescribed weight loss drugs

CON

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• Not as effective as other prescription weight loss pills

• Long-term health effects are not known

• Does not address real issues of overeating

• Can be mistakenly used as a magic pill to lose weight

• Very modest weight loss in comparison to other prescription weight loss pills and diet and exercise alone

DIET and NUTRITION

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At this time, it is not known if there are eating or dietary guidelines that must be followed while taking Lorcaserin. The medication is supposed to suppress appetite and produce feelings of satiety.

EXERCISE

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At this time, there is no information on what kind of a fitness routine is recommended.

CONCLUSION

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One of a trio of prescription weight loss pills that has been undergoing FDA trials and review in 2010, Lorcaserin works to suppress appetite by increasing the amount of the feel-good hormone, serotonin, in the brain. While this medication has the least amount of side effects in comparison to other medically-prescribed pills, its weight loss results are not that stellar.

Common Misspellings

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lorcasrin, lorcserin, lorsacerin, lorsarin, lorserin, loriserin

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