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FDA Looks Into Alli and Xenical Liver Damage Concerns

alli and xenicalNew research shows concern that two popular weight loss drugs, Alli and Xenical, may cause liver damage. On Monday, August 24, 2009, the Food and Drug Administration (FDA) began investigating recent reports that these drugs may be causing liver damage in those who take them.

To date, there have been 30 reported cases of liver damage by those who take Alli, the only non-prescription weight loss drug the FDA has approved, and Xenical, its prescription counterpart. Of the 30 reports, 27 individuals have been hospitalized and six of them have experienced liver failure.

Both drugs are marketed by British drugmaker GlaxoSmithKline PLC, but Xenical is manufactured by pharmaceutical giant Roche.

Proponents of the medications including a spokesperson for GlaxoSmithKline state that the liver damage may have nothing at all to do with Alli or Xenical use, but rather since liver disorders are common in those who are overweight or obese, these specific liver damage cases are likely due to excess body weight thereby predisposing them to such liver-related conditions.

While the FDA is carefully looking into these cases and determining how direct or indirect the link is between these two drugs and liver damage, the regulatory agency is encouraging all Alli and Xenical users to continue to use their medication according to their doctor’s guidance and to take careful notice of any early signs of liver damage which include nausea, unexplained fatigue, fever and vomiting. If any such signs are experienced, the individual should contact their medical provider as soon as possible. will continue to provide you with the most up-to-date information on this breakthrough health information.

August 25th, 2009

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(Page 1 of 1, 4 total comments)


alli was off the shelves and now its back on, has the recall been released?is it safe?

posted Jul 9th, 2012 7:33 pm


Just another example of why diet and exercise should be the only weight-loss method for the majority of us. Of course, TIME just argued that exercise doesn't help, but I disagree. I blogged about the TIME article

posted Aug 28th, 2009 3:28 pm


are they going to take this off that market?

posted Aug 25th, 2009 10:41 am

Diane Sharp

This is the first I have heard about this. Good to know! That is why we should wait for awhile before running to get the quick fix pill.

posted Aug 25th, 2009 10:39 am


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