What is it?
Picamilon is a nootropic product from Russia that is thought to help with reducing anxiety and promoting relaxation. It is also possible that it may improve energy levels, memory function, and subjective well-being.
Picamilon increases circulation throughout the body and helps the brain with GABA absorption. Both of these functions may potentially be helpful for short-term cognition and long-term neuroprotection.
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Picamilon Ingredients and Side Effects
Picamilon: A man-made drug that is synthesized by combining niacin and gamma-aminobutyric acid (GABA). Picamilon (also sometimes called pycamilon or pikamilon) is sold as a prescription drug in Russia, however it is not approved for sale in America.
Picamilon’s effects are not well studied at this time, and there is considerable debate about the validity of their findings. Manufacturers of Picamilon claim that it may possibly have the following nootropic benefits for its users:
- Improved memory performance
There is a lack of clinical validation for these claims, which seem to be based more on anecdotal evidence and data about its two component parts, niacin and GABA.
Niacin, also known as vitamin B3, is one of the essential human nutrients. We are unable to manufacture it naturally, however it is also required in order for proper functioning of the body.
Without B3, the body cannot process cholesterol, tryptophan, and serotonin properly. Other symptoms of B3 deficiency can include confusion, delirium, diarrhea, lesions on the skin, and it can lead to Hartnup disease or pellagra.
Niacin is a vasodilator that helps increase blood flow throughout the body, including to the brain. It is not considered a nootropic in and of itself, however increased cerebral blood flow is useful for improved mental function and long term brain health.
Niacin is used in Picamilon primarily as a bonding agent to help the GABA molecules cross the blood-brain barrier. GABA has a much more direct effect on mental functioning and is considered an important neuro amine, however its molecular structure has difficulty being absorbed on its own.
GABA is still not well understood scientifically, however it is considered a powerful relaxant that works to counter the stimulating qualities of glutamates. It is possible that it plays a role in memory function and learning, as well as in brain development in younger people.
GABA may also be involved in organ eye, and sexual function. It is manufactured normally in the brain, however some people can have difficulty with that process, especially as they start to age.
This may necessitate GABA supplementation, however as mentioned it can be difficult to absorb orally. Picamilon has been shown to be much better absorbed than GABA on its own, which makes the chemicals much more bioavailable.
Picamilon has not demonstrated any of these benefits in laboratory trials, however. There is very little concrete data about the differences of Picamilon and regular GABA and niacin supplements.
There have been some potentially detrimental effects associated with Picamilon usage, most significantly it can possibly cause rapid drops in blood pressure. This can cause hypotension, dizziness, and even loss of consciousness. Other side effects potentially related to Picamilon consumption may include:
It is unclear what benefits any individual user will experience, as its results tend to vary widely in past accounts of experiences.
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Picamilon Quality of Ingredients
Scientists and past users do not tend to be as enthusiastic about the abilities of Picamilon as its manufacturers and distributors are. While it may have some potentially beneficial effects to basic brain biofunctionality, it seems unlikely that it will be effective as a nootropic performance booster.
Picamilon does increase blood flow to the brain, which in general is beneficial for mental functionality. It also delivers niacin to the brain, which is necessary for basic functionality, however is unlikely to provide any sort of benefits above baseline levels.
The niacin is also useful because it helps make the GABA in Picamilon more accessible. GABA has shown some potential as a nootropic aid, but it may also not be particularly beneficial once general baselines of availability are reached.
One of the issues with using Picamilon as a nootropic aid is that it can also have sedating effects, which are not helpful to people that are trying to be more productive and alert. Students that are trying to use Picamilon as a study drug and professionals that are trying to remain active and productive throughout the day may find the use of Picamilon to be counterproductive.
American readers should also note that as of 2015 Picamilon is illegal to sell in the United States. It is also regulated or controlled in other countries as well, and a prescription may be required for purchase in some areas.
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The Price and Quality of Picamilon
Despite the restrictions that are placed on Picamilon sale, it is still widely available for purchase online, even for delivery inside the United States. Here are some of the online Picamilon distributors and the prices that they were quoting, as of the date of this article’s publication.
- Thought Foods: 1, 6-count sachet of 100mg Picamilon tablets: $7.14
- Thought Foods: 1, 60-count bottle of 100mg Picamilon tablets: $32.49
- JSC Pharmstand: 1, 30-count box of 50mg Picamilon tablets: $6.00
- Mind Nutrition Europe: 1, 90-count bottle of Picamilon capsules: $19.01
Potential customers should note that Picamilon is not the same as the “GABA-Plus” style supplements that recommend themselves as Picamilon replacements. If the niacin and GABA molecules are not chemically bonded then the GABA will not be absorbed, and the product becomes, essentially, an expensive vitamin B3 supplement.
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Business of Picamilon
Picamilon was first developed by the Russian pharmaceuticals company NPK ECHO. Their contact information is listed as:
Phone Number: (499) 400-27-54
Address: NPK ECHO does not publish their physical address online.
Users should be aware that neither NPK ECHO nor any of the other companies listed have FDA or FTC approval to sell their products. Depending on your shipping location, purchasing or distributing Picamilon may or may not be legal.
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Customer Opinions of Picamilon
There is quite a bit of debate online about the effectiveness of Picamilon. While it has his defenders, there has also been a considerable amount of backlash against it. Here are several of the comments taken from online forums about users’ experiences with Picamilon:
“Made me irritable. I snapped at people for small things, which is very unlike me. Other than that, I’m not really sure that it actually did anything.”
“I’ve tried it several times and found it quite useless. The one thing it did for me every time was give me an extreme niacin flush. I got bright red from ear to ear – sometimes for more than an hour or so. So embarrassing!”
“I once saw a guy in a restaurant fall over and need to be carried out. I asked them what he was on and the just said Pica. No idea how much the guy took, but that was scary.”
One of the main issues with Picamilon seems to be how variable its effectiveness is. It seems that even the same user can have very different effects from the drug at different times. Many of its defenders seemed to prefer it for recreational reasons as opposed to its nootropic benefits.
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Conclusion – Does Picamilon Work?
It is difficult to say how effective Picamilon actually is for a number of reasons. The first is that there is very little information about the drug in general; very few studies have been performed into its effects, and the results of the studies that have been performed are highly questionable.
Second is the inconsistency of the drug’s performance. Many users that once reported positive experiences have later said that it started doing nothing for them. Some people have mentioned fluctuations in blood pressure, but only in certain instances and not in others.
It is possible that Picamilon could ultimately have some use for vitamin B3 and GABA supplementation, which may have some nootropic benefits. Our panel of experts would need to see actual hard data that proves its effectiveness before they could recommend it to our readers, and its legal status would have to change.
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